Purine nucleotides
Apexbio Technology LLC GTP Solution (100 mM) 250uL
GTP also known as Guanosine-5 -triphosphate can be utilized in various molecular biology applications such as in vitro transcription RNA amplification and siRNA synthesis Additionally GTP plays a critical regulatory role in signal transduction as a phosphate or pyrophosphate messenger it activates G-proteins which subsequently initiate protein kinase-mediated signaling cascades thus influencing cellular behaviors including cell proliferation and differentiation GTP also serves as a high-energy nucleotide precursor participating in enzymatic synthesis processes of DNA and RNA This product is prepared from GTP trisodium salt with purity 99% (HPLC) as a clear colorless aqueous solution at a concentration of 100 mM and pH (25 C) of 7 0 0 1 free from DNase and RNase contamination
Medchemexpress LLC Guanosine 5'-diphosphate sodium | 43139-22-6 | 99.9% | 465.18 | 500 MG
Guanosine 5'-diphosphate sodium is a nucleoside diphosphate known for activating adenosine 5'-triphosphate-sensitive K+ channels. It acts as an iron mobilizer by forming a complex with hepcidin, which inhibits the hepcidin-ferroportin (FPN) interaction and modulates the IL-6/Stat-3 pathway. This compound has been shown to ameliorate Turpentine-induced anemia of inflammation (AI) in mice, especially when combined with FeSO4, highlighting its utility in AI research.
- Activates ATP-sensitive K+ channels.
- Mobilizes iron by inhibiting hepcidin-FPN interaction.
- Modulates IL-6/Stat-3 pathway.
- Ameliorates anemia of inflammation (AI).
- Increases iron absorption and FPN levels in liver, spleen, and enterocytes.
- Reduces iron storage ferritin and Stat-3 phosphorylation.
- Decreases Hamp mRNA and hepcidin expression.
Medchemexpress LLC Adenosine 5'-monophosphate disodium | 4578-31-8 | MFCD00065023 | 99.9% | 391.18 | 25 G
Adenosine 5'-monophosphate disodium is an orally active purine nucleotide involved in ATP metabolism. It also functions as a ligand for the adenosine 2B receptor. This compound can activate AMPK in skeletal muscle, which aids in ameliorating insulin resistance and impaired glucose metabolism, making it suitable for diabetes research.
- Orally active purine nucleotide
- Participates in ATP metabolism
- Acts as a ligand for the adenosine 2B receptor
- Activates AMPK in skeletal muscle
- Ameliorates insulin resistance
- Aids impaired glucose metabolism
- Useful for diabetes research
Medchemexpress LLC Adenosine 5'-monophosphate monohydrate | 18422-05-4 | 99.8% | C10H16N5O8P | 1 G
Adenosine 5'-monophosphate monohydrate | 18422-05-4 | 99.8% | C10H16N5O8P | 1 G
Crescent Chemical Co Inc ATP NA2 SALT CRYS RESEARCH GRD
Adenosine-5'-triphosphate-Na2-salt cryst. research grade Size - 5G Storage Conditions - -15 °C TO -25 °C Catalog Number - 10920.02 CAS 987-65-5
Medchemexpress LLC GTP-14564 | 34823-86-4 | 99.9% | 234.25 | 100 MG
GTP-14564 is a tyrosine kinase inhibitor that targets internal tandem duplication (ITD) and FLT3. It inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells.
- Tyrosine kinase inhibitor
- Targets internal tandem duplication (ITD) and FLT3
- Inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells
- For research use only
Medchemexpress LLC Guanosine 5'-triphosphate (trisodium salt) | 36051-31-7 | 95.0% | 1 G
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. It can promote myogenic cell differentiation by upregulating miRNA and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. It holds promise for research in biosynthesis and skeletal muscle regeneration.
- Is a G protein signaling activator
- Is a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA
- Can promote myogenic cell differentiation
- Upregulates miRNA (miR133a, miR133b) and myogenic regulatory factor expression
- Induces human myogenic precursor cells to release exosomes containing guanosine molecules
- Holds promise for research in biosynthesis and skeletal muscle regeneration
- For research use only
Medchemexpress LLC Adenosine receptor inhibitor 2 | 2550401-76-6 | 99.1% | 406.28 | 5 MG
Adenosine receptor inhibitor 2 (compound 14b) is a potent AR (adenosine receptor) inhibitor. It exhibits dual affinity toward A1/A2A ARs, with a higher affinity for the A1- than the A2AAR. The compound has Ki values of 52.2 nM for the A1AR and 167 nM for the A2AAR.
- Potent AR inhibitor
- Dual affinity toward A1/A2A ARs
- Higher affinity for A1AR (52.2 nM Ki)
- Lower affinity for A2AAR (167 nM Ki)
- Formula: C17H20BrN5O2
- Appearance: Solid
- Color: White to off-white
Apexbio Technology LLC 2-Amino-ATP(Synonyms: 2-NH2-ATP, 2-Aminoadenosine triphosphate, 2-Amino-adenosine-5'-triphosphate, 2-Amino-ATP (free acid)), 50ul (100 mM).
2-Amino-ATP is a modified nucleotide structurally related to ATP (adenosine triphosphate) featuring an amino substitution at the adenine ring s 2-position It acts as an ATP analog capable of competitively binding at the active sites of ATP-dependent enzymes potentially modulating their enzymatic activity and influencing downstream signaling pathways In research settings 2-Amino-ATP serves as a molecular tool to examine substrate specificity mechanistic aspects of ATP-binding enzymes (e g kinases and ATPases) and nucleotide-dependent receptor interactions facilitating studies of nucleotide signaling and cellular metabolism
Medchemexpress LLC Adenosine 5'-monophosphate (disodium) | 4578-31-8 | 99.6% | 391.18 | 500 MG
Adenosine 5'-monophosphate disodium is an orally active purine nucleotide that participates in ATP metabolism. It is also a ligand for the adenosine 2B receptor. It can activate AMPK in skeletal muscle, ameliorating insulin resistance and impaired glucose metabolism. This product can be used for research on diabetes.
- Orally active purine nucleotide
- Participates in ATP metabolism
- Ligand for adenosine 2B receptor
- Activates AMPK in skeletal muscle
- Ameliorates insulin resistance and impaired glucose metabolism
- Can be used for research of diabetes