Purine nucleotides
Apexbio Technology LLC GTP-Binding Protein Fragment, G alpha 25mg
GTP-Binding Protein Fragment G alpha is a peptide fragment derived from the amino-terminal region of the alpha subunit of GTP-binding proteins It is designed to aid in elucidating the mechanisms of membrane association and -subunit interactions in cell signaling pathways GTP-Binding Protein Fragment G alpha exerts its biological activity by retaining membrane-binding properties independent of the nucleotide-binding state anchoring the protein to the cytoplasmic membrane surface This peptide fragment serves as an experimental tool to study membrane-association mechanisms and signal transduction pathways in biochemical and biomedical research Based on these properties GTP-Binding Protein Fragment G alpha holds research potential in investigating the molecular basis of G protein-mediated signal transduction and protein-membrane interactions
Medchemexpress LLC Guanosine-15N5 | 99.6% | 288.21 | 1 MG
Guanosine-15N5 is an isotopically labeled form of Guanosine, where 15N (nitrogen-15) replaces the natural nitrogen atoms in the molecule. Guanosine is a purine nucleoside, formed by the attachment of guanine to a ribose sugar via a β-N9-glycosidic bond. This compound is primarily intended for research purposes.
- 15N labeled compound
- Purine nucleoside
- Formed from guanine and ribose
- Possesses anti-HSV activity
- Suitable for research applications
Medchemexpress LLC Inosine 5'-diphosphate sodium | 81012-88-6 | 98.2% | 512.15 | 50 MG
Inosine 5'-diphosphate sodium is a purine ribonucleoside 5'-diphosphate that features inosine as its nucleobase. This compound is known for its role in intracellular energy metabolism and signal transduction processes.
- A purine ribonucleoside 5'-diphosphate
- Inosine is the nucleobase
- Participates in intracellular energy metabolism
- Involved in signal transduction processes
- Relevant to respiratory disease research
- Applicable to metabolic or endocrine disease studies
- Used in pulmonary disease research
- Investigated in lung fibrosis studies
- Can be classified as an oligonucleotide
- Functions as a nucleotide analog
- Related to inosine compounds
- Identified as a nucleoside
Medchemexpress LLC Adenosine 5'-diphosphate sodium salt | 20398-34-9 | 98.0% | 100 MG
Adenosine 5'-diphosphate sodium salt is a nucleoside diphosphate and the product of ATP dephosphorylation by ATPases. It induces human platelet aggregation and inhibits stimulated adenylate cyclase through its action on P2T-purinergic receptors.
- Induces full maximal aggregation of human platelets with a pA50 of 5.87.
- Inhibits prostaglandin E1 (PGE1)-stimulated adenylate cyclase activity in human platelets by 71% at 5 μM for 30 seconds.
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 10mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Medchemexpress LLC 3-(5-(2-methyl-1H-imidazol-1-yl)-2-(pyrazin-2-ylamino)thiazol-4-yl)benzonitrile | 431040-19-6 | MFCD30747838 | 99.8% | 359.41 | C18H13N7S | 100 MG
Adenosine antagonist-1 is a research-grade small-molecule antagonist of the adenosine A3 receptor (AA3R) with reported anti-inflammatory activity. It is supplied as a solid powder and as a 10 mM solution in DMSO for use in biochemical, cellular, and preclinical studies; molecular formula C18H13N7S, molecular weight 359.41, CAS 431040-19-6.
- Selective adenosine A3 receptor antagonism for receptor biology studies.
- Reported anti-inflammatory activity in preclinical models.
- Available as solid powder or 10 mM solution in DMSO for flexible dosing.
- High purity suitable for biochemical and cellular assays.
- Molecular formula and weight provided for formulation and dosing calculations.
Medchemexpress LLC Adenosine 5'-monophosphate disodium | 4578-31-8 | 99.9% | 391.18 | 10 G
Adenosine 5'-monophosphate disodium is an orally active purine nucleotide that participates in ATP metabolism. It also serves as a ligand for the adenosine 2B receptor. This compound can activate AMPK in skeletal muscle, which helps to improve insulin resistance and impaired glucose metabolism, making it suitable for diabetes research.
- Orally active purine nucleotide
- Participates in ATP metabolism
- Ligand for adenosine 2B receptor
- Activates AMPK in skeletal muscle
- Ameliorates insulin resistance and impaired glucose metabolism
- Useful for research of diabetes
Medchemexpress LLC NHC-triphosphate tetraammonium | 97.09% | 567.28 | 1 MG
NHC-triphosphate tetraammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) in its triphosphate form. It acts as a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA.
- May directly target the viral polymerase and act as a nonobligate chain terminator
- Plays a significant role in inhibiting early negative-strand RNA synthesis
- Interferes with correct replicase complex formation through chain termination or mutagenesis
Apexbio Technology LLC Motesanib Diphosphate (AMG-706) 857876-30-3 10mM (in 1mL DMSO)
Motesanib Diphosphate (AMG-706 CAS 857876-30-3) is an oral small-molecule ATP-competitive inhibitor that targets vascular endothelial growth factor receptors (VEGFR1/2/3) platelet-derived growth factor receptor (PDGFR) c-Kit and Ret with reported IC50 values of 2 84 nM It demonstrates over 1000-fold selectivity for VEGFRs relative to EGFR Src and p38 kinases In vitro Motesanib Diphosphate potently inhibits VEGF-induced proliferation of human endothelial cells (IC50 10 nM) and blocks PDGF- and SCF-induced signaling while showing minimal effects on bFGF-stimulated proliferation In preclinical studies it suppresses angiogenesis and induces regression in tumor xenograft models Motesanib is under investigation in anti-angiogenic cancer research
Apexbio Technology LLC 2'-O-Methyl-N6-Methyl-ATP 100ul (100 mM)
2p-O-Methyl-N6-Methyl-ATP is a chemically modified ATP analog bearing methyl substitutions at the N6 position of adenine and the 2 -hydroxyl group of the ribose sugar 2p-O-Methyl-N6-Methyl-ATP is designed to facilitate the study of RNA methylation processes and RNA protein interactions supporting the mechanistic exploration of RNA-modifying enzymes and epigenetic regulatory pathways Based on these properties 2p-O-Methyl-N6-Methyl-ATP holds research potential in investigations of ligand RNA interactions and drug discovery applications targeting RNA-related biological processes
Medchemexpress LLC Adenosine 2',3'-cyclic phosphate sodium | 37063-35-7 | 99.1% | 351.19 | 5 MG
Adenosine 2',3'-cyclic phosphate sodium is a 2',3'-cyclic purine nucleotide. It is deaminated by adenosine deaminase and can be degraded to 2'-AMP and 3'-AMP.
- Efficiently hydrolyzed by the monocations of alkylenediamines at pH 9.0, 50°C.
- Deaminated by adenosine deaminase from Drosophila larvae.
Cell Signaling Technology ATP-Citrate Lyase (D1X6P) Rabbit mAb 20 ul
ATP-Citrate Lyase (D1X6P) Rabbit mAb 20 ul
